Tuesday, January 31, 2012

SB XLVI Guide is your personal Super Bowl guide in your pocket

If you're heading to the Super Bowl this weekend, SB XLVI Guide will be your companion in your pocket. It's your guide to official Super Bowl events, a map of Indianapolis, a 3D map and seating chart to the Lucas Oil Stadium, and a reference for local restaurants and nightlife.


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/_VLeFtAngew/story01.htm

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VIDEO: The Best Shameless End Tag You May Have Missed (omg!)

Joan Cusack, Shameless  | Photo Credits: Chuck Hodes/Showtime

If viewers didn't stick around for Shameless' hilarious end tags, they missed a plane falling out of the sky on Sunday's episode.

No, this isn't Lost. Agoraphobe Sheila (Joan Cusack) has been making huge strides throughout the season, venturing just a few steps farther out her door every day. When it seems Sheila will make it to the local watering hole ? where she might learn the real truth of Frank's boozing, scheming ways ? Frank's prayers are answered when a giant piece of an airplane's landing gear falls precariously close to Sheila outside her home, sending her running back inside for comfort.

Photo Gallery: Winter TV's sexiest eye candy

Not that Shameless needed to drop a plane to get anyone's attention, but executive producer John Wells says he hopes this will get people to stick around for the show's dirty, pithy end tags.

He says that a problem with network television now is that at the end of the show "you're assaulted immediately by the local newscast or whatever it is. No matter how well you craft the end of the show to have an emotional response, it's interrupted almost immediately by some other piece of information. By putting the tags in we force everybody to stick around to see that there's something else coming up."

In case viewers did miss the tag, Sheila's return to her agoraphobic state will be explained at the beginning of next Sunday's episode. Just don't expect her leave the house again anytime soon. "She goes back into the covers for a while," Wells says. "She is constantly struggling with her own personal demons and trying to figure out how to move forward in her life."

Check out the best Shameless tag you may have missed:

Must See HDTV (January 30th - February 5th)

This week is all about the big game, but even if you're not watching the Super Bowl, there's a lot to tune in for. We've got a slew of new premieres, plenty of NBA and NHL action, and even an old favorite coming home on Blu-ray. Look below for the highlights this week, followed after the break by our weekly listing of what to look out for in TV, Blu-ray and videogames.

Star Trek: The Next Generation - The Next Level
One of the best science fiction series ever returns, this week, remastered and in HD. Check after the break for a video splitscreen showing off the original video crossed over with the new special effects, which were recomposited back on top of the original film negatives for what seems to be an incredible new experience. Not every revisitation in the past has gotten a positive reception, but it appears this is one fans will enjoy. The release this week is a quick three episode teaser of what's to come, the full meal of season one is still on the way later this year.
(January 31st, $14.99 on Amazon)

Super Bowl XLVI
*Cough*
(February 5th, NBC, 6PM)

I Just Want My Pants Back
Yet another young adult dramedy on MTV, but after the solid efforts of RJ Berger and Awkward (we're going to pretend the ill-fated port of Skins never happened) it may be worth a shot. The title comes from the main character, who is left looking for his pants which were taken by a particularly special one night stand that he's trying to find in the big city. Yeah.
(February 2nd, MTV, 11PM)

Continue reading Must See HDTV (January 30th - February 5th)

Must See HDTV (January 30th - February 5th) originally appeared on Engadget on Mon, 30 Jan 2012 18:03:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/01/30/must-see-hdtv-january-30th-february-5th/

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Daniel Radcliffe Talks The Woman in Black

Daniel Radcliffe seems content with, as he puts it, the fading "hoopla" that surrounded playing Harry Potter for ten years. "If that steadily decreases for the rest of my life, I'll be kind of cool with that," Radcliffe admitted on the eve of the release "The Woman in Black," his first post-Potter film project. Considering his fame -- primarily fueled from playing Potter in eight separate films -- the 22-year-old actor is surprisingly self-aware.

Radcliffe realizes his current place in movie stardom. He knows that his "cachet" (again, as he puts it) will not last forever, nor do I get the impression that he wants it to last forever. Actually, from the time we spent together, I did get a vibe from Radcliffe that almost cried, "the sooner, the better." Put it this way: when searching for an apt metaphor to describe fame and fortune, Radcliffe compared it to regurgitated steak.

In "The Woman in Black" Radcliffe plays Arthur Kipp, a lawyer who discovers deep, dark secrets in a town inhabited by a seemingly child-killing ghost. An open and honest Radcliffe discussed the importance of his first post-Potter role, why he would not play another character named "Harry," and what he won't miss about the fame that came along with being Harry Potter.

They didn't screen the film for me before this interview.
I'm sorry.

I've seen the trailer. In the time we have, you could act out every scene that I've seen five times.
That's absolutely true! Yes! And it would be a lot of the same face that's in the trailer.

So you're 22 now, right?
Yes.

You do look a little older in "The Woman in Black" than what we're used to seeing.
Good.

Is that important to you?
Yep.

Why?
In the original script he's about 27. I think I could conceivably play 24 or 25 with a little bit of stubble. Also, in all of those clothes, that makes you look slightly older because you hold yourself differently. So, yeah, we were picturing him at about 24 or 25, with a 4-year old son.

Did you read the book?
Yes. I've read the book, but I've never seen the play. Weirdly, because I never really was at school -- because the play seems to be like a "school trip" play for everybody I know -- I never went to see it because I was doing "Potter." But I hear it's terrifying -- as it should be.

It would be odd if you said, "I've heard that it's hilarious."
[Laughs] Yeah, well that's the thing: the movie is very different than the book and very different than the play. And the book is different than the play. So, you know, we've all taken liberties. The original book is told in the past -- it's flashback from my character as an old man -- and that's not what it is in the film. In the film it all takes place in the present time. It's basically the idea for "The Woman in Black," the village and the tone of the book, and changed details of the story.

What if the main character's first name in this story was Harry instead of Arthur? Maybe that's a stupid question...
No, it's not stupid at all.

Would you have asked to have it changed?
Yeah, I think I might.

That's interesting.
I don't know. I think I might. It would be more of a problem if the character's name was Potter. That would be worse. But, I don't know. Maybe. On "My Boy Jack," they came to me with glasses and I was like, "Whoa, not those ones." But, yes, it's not a stupid question; it's quite an interesting one. Yeah, I think I might have asked for that to be changed. I'm not sure. I don't know how I would have felt about that. But, yeah, there's also another weird "Potter" connection with this: the guy who played my dad in "Potter" played my character in the original TV film of "The Woman in Black." So there's a few little weird "Potter" connections. But, then again, "Potter" is connected to everything. It's no no longer even a coincidence. It's just inevitable.

This is your first big film role post-"Potter." How important is this movie to you?
It's important, but it's not the be-all and end-all, that's the thing. Like, people keep saying, "Oh, it's Daniel Radciffe's first film post-"Harry Potter," let's see how he does."

I don't even necessarily mean it like that. Do you feel you need to separate yourself from what you're currently known for?
Yes. But I think it's a longer... I think to put all of that pressure on one film would be ridiculous. I think, because not everyone is going to see this. A lot of people will, hopefully, but not everyone. And, also, I made peace a long time ago with the fans. There will be people who forever see me as Harry. That's fine as long as they're not controlling a casting racket in L.A., then we'll be fine. For this film, what's great about it and what's kind of perfect is that the part is different: it's older, it's playing a father. There are challenges there; stuff that will physically separate me from Harry in people's minds. But there's also the story is so compelling that after about 10 or 15 minutes of watching the film, you're going to stop thinking about me or what else I've done and just be into the film. Because it's a really brilliant story. So that's why it's kind of perfect as a first film outside of it. Because even though I'm the only "name above the title" kind of thing, once you're in there, it's not about me. it's about the story and the need to know what's going to happen. So, hopefully that will overtake.

Will you miss all the commotion that came with Harry Potter? If I were you, I can't decide if I'd miss it or not.
[Pauses] Hm...

Not the people that you worked with...
No, no, no... the fame and the circus and the hoopla...

"Hoopla." That's the word I'm looking for.
No, I don't miss the hoopla. I don't think, particularly. I'm quite happy. If I have passed my most famous point, I won't be unhappy. Like, that's OK. If, say, around the time of "Potter 7" coming out, my face is all over the world, and all of that stuff is going on at that time and all of that madness -- if that steadily decreases for the rest of my life, I'll be kind of cool with that. I had a good dose of it for 10 years. You know, I'm now content to just make my way and do a lot of films that I find interesting. There is the fight, then, is that in order to keep being able to do interesting little things, you have to do that George Clooney thing of doing a big movie like an "Oceans 11" -- which are still very good movies -- so that you can go off and do "Syriana" or "Good Night and Good Luck," or whatever. So I suppose that's the challenge in the future. For now, I still have "Potter" behind me and people still associate me with this big thing. So, while my name has some cachet, I guess...

It does.
It does, for now. But, you know, it won't forever. And, so, while it still does, I've got a chance to make some really interesting films.

So when you look at the hoopla, what part are you most glad is over? Is it so you have time to make different movies?
That's the thing...

You had time for stage productions...
But not for films. I won't miss having to tell people, "No, I won't be available for another year and a half." I won't miss that. Look, there's always going to be premieres and all of that. That kind of stuff. I won't miss the mania that kind of surrounds it. But it's not like I disliked any of that at the same time. it's one of those things where you go, I don't know -- it's the equivalent of having a really, really good steak. Like, you have it, then it's gone. You don't miss it. You don't go, "Oh, I wish that steak were back here." You go, "Damn, I enjoyed that."

I've missed steak before.
OK, but you don't want to regurgitate it and eat it again!

That's fair.
But that's the kind of thing I'd say about "Potter." It was like a good steak for 10 years, I enjoyed it, but I wouldn't try and bring it back up.

At one point you were attached to play photographer Dan Eldon. What happened?
Yeah, yeah... I was attached to that for a while. We felt that the script changes were needed.

My ex-girlfriend went to high school with him, so it's a project that I've paid attention to.
Oh, really? Yeah, it was a great script. And then I read a little more about his life and the script was fantastic, but it wasn't entirely -- reading about Dan, as well as being an inspirational and amazing person, he was also abrasive. And he annoyed a lot of people. He had a knack for pissing people off.

I've heard that.
And that wasn't in the script. And I felt that it needed that. So, yeah, that was the reason for that.

Mike Ryan is the senior writer for Moviefone. He has written for Wired Magazine, VanityFair.com, GQ.com, New York Magazine and Movieline. He likes Star Wars a lot. You can contact Mike Ryan directly on Twitter

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Source: http://www.rottentomatoes.com/m/1924406/news/1924406/

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Video: Syria violence escalates

President Bashar Assad?s regime has slaughtered thousands of people since March, according to the United Nations. NBC?s Ayman Mohyeldin reports.

>>> in ssyria, the violence has gone from bad to worse. they are crushing the anti-government protests going on since last march. am am aman m aman is with us tonight.

>> it is firmly under its control. the situation is so dangerous that the arab league suspended operations. this as the united nations convenes on tuesday to discuss a resolution that calls on the president to step down from power immediately.

>> you are neigh cairo. give as report on the situation there.

>> reporter: a handful of americans that work for ngos here have taken refuge at the american embassy . the white house says they are not in imminent danger, but there is no real reason why they've gone to the embassy. they are being investigated for receiving money abroad and channelling it to political parties here, which would be a crime under egyptian law . the real test will be if the americans are charged with any crimes, would the u.s. embassy hand them over to egyptian authorities.

>> thanks.

Source: http://video.msnbc.msn.com/nightly-news/46196526/

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Johnson, Williams carry No. 10 Miami women past BC (AP)

BOSTON ? Shenise Johnson scored 16 of her 22 points in the opening half to lead No. 10 Miami to its eighth straight win, an 88-57 rout over Boston College on Sunday.

The Hurricanes (19-3, 8-1 Atlantic Coast Conference) never trailed and pulled to a double digit lead on Riquna Williams' basket in the lane 5:44 into the game. Their advantage never dropped into single digits the rest of the way.

Williams had 15 of her 18 points in the first half while Stefanie Yderstrom added 15 points for Miami, which hasn't lost since dropping its conference opener at North Carolina on Jan. 2.

Tessah Holt paced Boston College (5-16, 0-8) with 12 points. The Eagles have lost eight straight.

Williams, who needs six points to become the program's fifth player to reach 2,000, also grabbed eight rebounds. Johnson became the fourth to reach the 2,000-point mark earlier this season.

Miami missed its first two shots from the floor before its superior tandem of Johnson and Williams combined with its pressure defense to take charge.

Johnson missed the first shot of the game ? a short jumper in the lane ? but hit six of her next eight during the first half. She scored eight of her team's initial 16 points as the Hurricanes pulled to a 13-point lead on her 3-pointer.

After Johnson's offensive surge, Williams dominated, scoring 11 straight Miami points and 13 of 16 as the Hurricanes pushed their lead to 27-11 midway into the half.

Johnson's two free throws gave the Hurricanes a 41-16 edge, their largest lead in the opening half.

Miami, which forced 15 turnovers in the opening 20 minutes, led 48-27 at intermission.

The Hurricanes pushed their lead over 30 points (61-29) on Williams' basket early into the second half. They came out after intermission and scored 13 of the initial 15 points, making sure the Eagles wouldn't give them any threat.

Williams came down awkwardly after a basket late in the first half and walked to the bench gingerly, but she started the second half.

The Hurricanes entered the game leading the conference averaging 14.3 steals per game.

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/ap/20120130/ap_on_sp_co_ga_su/bkw_t25_miami_boston_college

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Monday, January 30, 2012

From the Field: Hazed Tells Her Story of Harassment

Today I?m going to share something different with you all. Because of this blog, I get a lot of email and contact with women who have stories to tell about their experiences in science. I have heard enough of these by now, stories of harassment and assault, of belittling and being passed over, of subtle and overt sexism, that I feel it?s time to share some of them. What I?ve noticed from these stories is that some individuals, when doing field research in foreign countries, behave in ways that would be considered morally repugnant at home. My hope is that if more people see the reality of these stories, we can work towards solutions around better community monitoring, speaking up, and institutional change.

Deciding to share one?s story is a brave, and in some cases dangerous act. Therefore, in the story you are about to read, the author and I decided to change a few details to protect her anonymity.

* * *

When I began to experience sexual harassment as a graduate student, I felt I was being hazed. As one of few female students in a male-dominated field, I assumed my professor wanted to see how tough I was.? I must say, I rose to the challenge.? I laughed off his and other male students? sexualized banter and came back with insults of my own in an attempt to fit in.? I was a young, enthusiastic researcher and I wanted to be accepted. I interacted with my professor and male colleagues informally, not realizing how badly it could backfire. As time passed I became a target, rather than a participant in the joking.

In moments of discomfort, I kept my feelings to myself.? At our research site in a foreign country, my professor and the male students often made lewd comments about the local women.? One day early in my training, my professor took us on a tour of a rural town.? We came across a friendly young pregnant woman and her husband.? My professor chatted with the couple in their language then turned to me. In English, he commented approvingly upon the woman?s breasts.? Her husband realized what he was saying and ordered his wife to cover up.? The young woman quickly drew her shawl across her chest, eyes cast to the ground. My professor seemed unconcerned about the humiliation he caused them. I was put off by his lack of respect, but I said nothing.? The incident has nagged at me for years.

My professor often joked that only pretty women were allowed to work for him, which led me to wonder if my intellect and skills had ever mattered. He asked very personal questions about my romantic life, often in the presence of the male students. His inappropriate behavior was a model for them, making it not only acceptable, but the norm. My body and my sexuality were openly discussed by my professor and the male students. Comments ensued about the large size of my breasts and there was speculation about my sexual history. There were jokes about selling me as a prostitute on the local market. Once I mentioned that I admired a senior female scientist and they began describing scenarios in which she and I would have sex. Pornographic photos appeared daily in my private workspace. What started out as seemingly harmless joking spiraled out of control. I felt marginalized and under attack, and my work performance suffered as a result.

Often, I was left with a pile of work at night while my professor and his male students went out to bars.? They enjoyed the attention of local women, who were attracted to their wealth and prestige as foreigners. Many of my co-workers engaged in affairs with local women. On the other hand, I received unwanted attention if I went out unaccompanied. Local men would follow me down the street, making catcalls, sometimes groping me.? Foreign women were often treated that way.? Because of this, I became increasingly reliant on the men I worked with, though I felt nearly as unsafe at work as I did in the streets.

By the time the harassment got out of control, it was too late for me to back out. I had spent too many years immersed in the research to walk away and start over.? So I modified my own behavior, hoping things might change. I dressed as modestly as possible to avoid drawing attention to my body, but the sexual comments continued. I tried dating one of the male students, thinking that if I had a boyfriend I would be protected. But the romance fizzled, leaving me more vulnerable to humiliation than before. I also tried working twice as hard as everyone else, but my professor never noticed.

I finally confronted my professor, out of desperation rather than courage. It didn?t go very well. He told me that I was oversensitive and that I kept talking like that he?d fire me. And for many reasons, mainly shattered self-esteem, I stayed. The most blatant sexual jokes and comments stopped.? My professor curbed his comments out of fear of the consequences. But our relationship deteriorated so much after that conversation that he eventually revoked his promise to fund me through graduate school.

In the early days of my research I knew nothing of academic life. I didn?t realize that many research projects are run like pyramid schemes, with rigid status hierarchies, ruthless competition, the exploitation of students and objectification of women.? I realized too late the extent of the strings attached to the funding my professor had promised. My education was compromised for no reason other than my femaleness.

When a professor makes the commitment to mentor a student, the student?s professional future is in their hands. This should never be taken lightly, and in the case of male professors and female students, it is crucial to maintain ethical boundaries. Women students at foreign research sites are particularly disempowered, being far from family and other support networks. This is the kind of setting in which the power imbalance between student and professor can be exploited.

I have read about sexual harassment lawsuits underway at Yale University.? Some of the stories are eerily similar to mine. We start with a young, enthusiastic, intelligent woman.? A male professor takes an intellectual interest in her, takes her under his wing, gives her a job and training.? When the inappropriate comments start, she feels uncomfortable, but says nothing. She feels indebted to the professor, and he has promised to guide her to a successful career.? She becomes deeply engaged in and committed to the research, but the professor continues to pester and demean her.? She feels increasingly insecure, and she must decide whether to confront her harasser or leave the research she loves. She has to pay a price, simply for being a woman.

Someone always asks, ?Why didn?t she just leave?? Well, she might not leave because she is funded, and there aren?t many other opportunities. She may be too committed to the research.? She could be years into a graduate program, and changing professors would slow her progress to graduation substantially.? Potential new professors will want to know why she left, and it will be difficult to answer.? Others in her field will think she is an unreliable scholar for switching horses midstream. Her professor may refuse to give her a recommendation, limiting her options. She knows her life and her choices will become subject to public scrutiny. She knows that some would say that she was ?asking for it.?? Finally, she knows that there is a lot to be lost from standing up to an abusive professor.

What can we do about this? Individual responsibility is fundamental, and many women do set boundaries and investigate potential graduate programs for any history of sexual harassment.? I wish I had thought of that. But it is not enough to place all responsibility on the would-be victims.? Women students deserve to have the same learning options that male students do. In this day and age women should not have to forego certain educational opportunities out of fear of being demoralized, harassed or abused. Universities must hold their professors accountable for their actions.? There must be a safe place for women to present their concerns about harassment without having to risk their futures. I also believe that professors with a record of harassment should be ineligible for research funding until they demonstrate a commitment to professional conduct.

I managed to graduate and have a great job doing research I love, but I bet a lot of women in these situations don?t. ?Fortunately I have discovered a community of brilliant, outspoken and supportive female scientists.? If I?d had role models like them as a graduate student, things would have been very different.

To the women who have had experiences similar to mine, I hope you are healing, and I hope you consider sharing your story. And to any women who are currently in such a situation, you are not alone. Don?t be afraid to reach out for support.? As I?ve learned the hard way, women in academia really need to look out for each other.

Source: http://rss.sciam.com/click.phdo?i=ab874e195e2119b9af5ae73e36c46ca0

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A Weekly Roundup of Small-Business News - NYTimes.com

Dashboard

A weekly roundup of small-business developments.

What?s affecting me, my clients and other small-business owners this week.

The Big Story: The President Sings

In his annual State of the Union address, President Obama cranked up the populist pitch. The G.O.P. responded. Representative Sam Graves outlined what he thought small businesses wanted to hear but small-business owners were split. A small-business owner in West Virginia was excited. One study finds small-business owners are dissatisfied with all of the presidential candidates. Joel Kotkin says ?this is America?s moment ? if Washington doesn?t blow it.? Your cellphone can now sing like the president.

Davos Update: An Intern Is Bored

As the sun bombards Earth with radiation, billionaires occupy Davos and bemoan the inequality of incomes. Their outlook is gloomy. Haley Amber Feinberg, a fictional intern, checks in: ?Attended my first panel: ?Tolerating the Unemployed.? Was really boring, played Crackgammon on my phone?s Facebook app the whole time.?

The Economy: The Baltic Dry Index

Even though chief financial officers do not plan significant expansion (pdf) in 2012, Thomas Black at Bloomberg reports that companies from General Electric to Chobani, a yogurt producer, are adding workers and leading a rebound in hiring. M.B.A. employment figures are another reason for economic optimism. Tech hiring is strong. The Federal Reserve chairman promises to keep rates low. Paul Krugman is feeling better. Durable goods orders jump, but the Baltic Dry Index records a disturbingly large drop. Travel on all roads and streets declined in November 2011, but the trucking industry posts its biggest jump in tonnage in 13 years. President Obama delays his 2013 budget. Steven Rattner says it?s dangerous when economists claim that debt doesn?t matter.

Sales and Marketing 1: A Twitter Lesson

American Express succeeds at a Facebook campaign, while McDonald?s suffers the wrath of Twitter. Flowtown creates a cool small-business social media infographic. An educational institution spends more on Google advertising than Apple, eBay, State Farm and AT&T. Retailers were the second-largest source of Google ad revenue in 2011. A study finds that while lots of small-business owners believe social media are important only a few tap its power. John Donahoe, chief executive of eBay, believes we?re going to see more change in how consumers shop and pay in the next three years than we saw in the last 20.

Sales and Marketing 2: The Power of Bieber

Lori Richardson names five attributes of top sales influencers. Devin Cole explains how to network. Google takes its daily deals to five new cities. Trendcentral discusses three new crowdfunding services. Our patience for Web ads lasts, oh, about 15 seconds. A location-based shopping app, Shopkick, has three million users. Christopher Penn shows that vintage ads can teach a lot about e-mail marketing design. Derek Johnson explains how to measure success with text-message advertising. Justin Kownacki explains how Justin Bieber ruined his life: ?Evidently, Mr. Bieber (or his handlers) saw my tweet and ? decided that I was a bloke worth following. And that one single button click momentarily ruined my life.?

Ideas: A Professional Laugher?

A new service helps people save money and resources by sharing stuff with community and friends. This is the place to go if you?re in the market for a professional laugher. Virtual internships are experiencing a rise in demand. Patrick Smith finds a few unexpected pleasures at our airports. David Bakke explains how he started his side business with Scotch tape and offers this simple advice: ?For the most part, I bought and sold products with which I was familiar.? Here are 10 reasons some companies succeed and others fail. Debbie McDonnell offers ideas for choosing a business name, including: ?Count the characters. Google AdWords permits 25 characters so a business name longer than this means having to abbreviate the name if you advertise there. Even if you don?t plan to advertise here initially, allow for it as it tends to be one of the most cost-effective ways of advertising.? Walmart offers a chance to sell ?in the big box.? This mountaintop ride seems like a bad idea.

Around the Country: Cashing In

Female business owners wave a magic wand in Portland, Ore. Houston?s businesses are hiring. A bunch of Indiana businesses plan to cash in on the Super Bowl. Maine is open for business, according to its governor. The start-ups in Brevard County, Fla., are finding that investors are still cautious. Illinois teenagers face bleak job prospects, but a marketing company gives teenagers with ideas the chance to win cash and fame. Manufacturing activity in the Chicago and central Atlantic regions advances. Steven Tyler gives an embarrassing rendition of the national anthem and a New York City school sign is embarrassingly misspelled. A coming Small Business Summit extends its ?strategy award? nomination deadline to Feb. 10. An accountant offers a small-business survival guide webinar on Tuesday. A Staples contest offers a free TV commercial as its prize.

Around the World: Press Freedom

A 375-year-old French bank forgives the debts of Paris?s poor. The United States drops 27 places on an index of press freedom. As Big Ben and the Houses of Parliament sink and the country slips into recession, Britain?s prime minister has an idea: let businesses occupy empty Government offices! Iran?s trade with China soars, and Chinese solar companies are found to be selling below cost. Wenguang Huang explains why Chinese entrepreneurs want to invest in the United States. The International Monetary Fund says Europe poses a global recession threat. Eleven years of Dubai?s growth can now be seen from space. A new satellite takes spectacular pictures of Earth.

Finances: Employee Expense Reports

As lending accelerates, Jamie Dimon discusses the state of banking. Catherine Clifford explains how community development financial institutions can help start-ups. Barry Moltz suggests where companies can find short-term cash. Accounting Today has a slide show on the most unusual items found in employee expense reports. A company offers a Weight Watchers-type service to help us ?set financial goals (and actually meet them).?

Boss of the Week

Christian Wentz?s Cambridge, Mass., start-up is developing a ?wireless router for the brain? that will make it possible to collect data from the brain: ?The data could then be wirelessly transmitted to a computer.? (On the other hand, this guy is not performing like a boss.)

Technology: Apple Is Flush

After a blow-out quarter, Apple has $97.6 billion in the bank and now we know why! Google starts tracking small businesses more closely ? here?s how to find out what the company knows about you. Twitter is going to censor posts. With new ad rollouts to come, Twitter acquires an antimalware start-up. Bill George explains how I.B.M.?s Sam Palmisano redefined the global corporation. Meanwhile, I.B.M. selects its global start-up entrepreneur finalists and is gearing up to challenge Google Docs and Microsoft Office 365. A Microsoft executive says a gay marriage law in Washington State is essential to the company?s competitive edge. Craftsmen creates a garage door opener with very remote control. Almost a third of all Americans now own a tablet or digital reading device. Information Week shares nine password security policy suggestions.

The Week?s Bests

Reason my kids should go to China. Wendy Kaufman tells how a trip to China changed how she ran her business: ?A C.E.O. that I met in China explained that he so passionately believes in the importance of honoring elders that he would only marry his wife if she treated his parents as her own. In the Chinese culture, family is so valued there is always someone caring for the family member. This type of work/life balance helps improve quality of care in both business and family interactions.?

Lessons from the big guys. Phil Simon shares six things he?s learned from big companies, including, ?Be sticky?: ?Attracting customers with your great products and services is step one. But getting them to stay with you ? and only you ? is the ultimate goal. With the launch of its Kindle Fire, Amazon just got stickier by making it easier for users to shop at Amazon and consume media and entertainment at Amazon than anywhere else. How can your business lure in customers and keep them there? With amazing customer service, follow-up, regular e-mail specials or contests? With interactive features at your Web site, birthday coupons or preferred customer perks? Make it hard for your customers to want to go anywhere else.?

Ways to manage time. Michael Costigan offers great advice on time management, including, ?Find someone else to crack the whip?: ?I find that it helps to have someone hold you accountable. Whether it?s a team member or an assistant, ask them to keep on you about getting things done. Sometimes the best way to make sure you do the things you need to do is by positioning the involvement of other people. That way, you aren?t just letting yourself down if something doesn?t get completed, you?re letting them and maybe the entire team down. And depending on how critical the tasks are, that could mean meeting payroll.?

This Week?s Question: What should McDonald?s have done differently on Twitter ? or was disaster inevitable?

Gene Marks owns the Marks Group, a Bala Cynwyd, Pa., consulting firm that helps clients with customer relationship management. You can follow him on Twitter.

Source: http://boss.blogs.nytimes.com/2012/01/30/this-week-in-small-business-a-twitter-lesson/

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Expected Growth in the Communications Field Entices Students to ...

Our online degree rankings are primarily based on several factors, including faculty and program popularity, peer and educational quality, and general affordability.

communication-degreeAlthough Americans have been experiencing an economic downturn, according to a recent report from Veronis Suhler Stevenson, the U.S. communications industry is projected to increase at a 5.5 percent compound annual growth rate from 2010 to 2015 to $1.41 trillion.

This growth comes on the heels of the explosion of Internet-based computer and mobile technologies, which are expected to continue to evolve and flourish.

For prospective students, this proves there has never been a better time to obtain a communication degree or further their education with a Masters in Communication.

Featuring the benefits and requirements for obtaining a communication degree or Masters in Communication, CommunicationDegreeGuides.org informs people about the important things to consider when advancing their education. These essentials include admissions prerequisites, majors, tuition and curriculum, and more. Visitors can also learn about the variety of career opportunities and potential salaries within the communications industry.

Due to the flexibility and affordability of online degrees, an increasing number of people are choosing to pursue their communication degree through Internet-based programs.

But according to CommunicationDegreeGuides.org, because online communication degrees can vary greatly in quality, it is essential to perform extensive research to find the top-rated program.

?To assist with that investigation, we?ve put together a rating of what we have determined to be the most effective online and distance studying master?s degree programs in communication, journalism and public relations,? states the site. ?Our online degree rankings are primarily based on several factors, including faculty and program popularity, peer and educational quality, and general affordability.?

CommunicationDegreeGuides.org also offers a guide to some of the careers available to people once they have obtained their communication degree or Masters in Communications. These include jobs within the marketing, advertising, public relations, political science, financial, sales and non-profit sectors.

Advanced communication skills are considered by companies to be one of the most desired traits in employees. To develop their interpersonal skills even further and make themselves a more valuable asset to future employers, numerous people are choosing to acquire a higher degree.

To learn the benefits of obtaining a communication degree or Masters in Communication, visit http://www.CommunicationDegreeGuides.org

About CommunicationDegreeGuides.org:

CommunicationDegreeGuides.org provides visitors with the array of benefits associated with acquiring a communications degree or masters in communication. Featuring an assortment of information pertaining to the communications field, people can read about topics such as typical salary ranges, available positions, education requirements and prerequisites and more.

Source: Press Release Distribution

Source: http://londonnewsfeed.com/expected-growth-in-the-communications-field-entices-students-to-obtain-a-masters-in-communication/

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Sunday, January 29, 2012

The Ecommerce Revolution Is All About You

AmazonPersonal recommendations have always been a part of ecommerce, but there has been little innovation since Amazon introduced retail and product personalization 10 years ago. But with the increasing mountains of data at digital retailers' fingertips, ecommerce is about to get even more personal. The fact is that right now there is little iteration from personalized ecommerce beyond what is taking place on Amazon. So you'll see suggestions of what other shoppers who bought a certain item also purchased, or recommendations to similar items to what you have purchased, but there is a whole world of social data, and even more-in-depth purchase data that can be mined by retailers to help increase sales.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/EV7tPNRxCOY/

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Congress tries to police itself on insider trading (AP)

WASHINGTON ? Aware that most Americans would like to dump them all, members of Congress hope to regain some sense of trust by subjecting themselves to tougher penalties for insider trading and requiring they disclose stock transactions within 30 days.

A procedural vote Monday would allow the Senate later this week to pass a bill prohibiting members of Congress from using nonpublic information for their own personal benefit or "tipping" others to inside information that they could trade on.

Insider trading laws apply to all Americans, but CBS' "60 Minutes" in November said members of Congress get a pass, citing investment transactions by party leaders and a committee chairman in businesses about to be affected by pending legislation.

The broadcast report raised questions about trades of House Speaker John Boehner, R-Ohio; the husband of Democratic leader and former Speaker Nancy Pelosi of California; and Rep. Spencer Bachus, R-Ala., chairman of the House Financial Services Committee.

All three denied using any insider information to make stock trades, but the broadcast set off a flurry of efforts in Washington to deal with the public perception.

A recent Wall Street Journal/NBC News poll of registered voters found 56 percent of them favor replacing the entire 535-member Congress. Other polls this year have given Congress an approval rating between 11 percent and 13 percent, while disapproval percentages have ranged from 79 percent to 86 percent.

House Majority Leader Eric Cantor, R-Va., said he's working on an expanded bill that would go beyond stock transactions and ban lawmakers from making land deals and other investments based on what they learned as members of Congress.

The Senate version of the Stop Trading on Congressional Knowledge (STOCK) Act would subject any member of Congress who violates the ban on insider trading to investigation and prosecution by regulatory agencies and the Justice Department. It also directs the House and Senate ethics committees to write rules that would make violators subject to additional congressional penalties.

"We can start restoring some of the faith that's been lost in our government by taking this common sense step of making members of Congress play by the exact same rules as everyone else," said Sen. Kirsten Gillibrand, D-N.Y., who with Sen. Scott Brown, R-Mass., wrote the bill "We must make it unambiguous that this kind of behavior is illegal."

President Barack Obama endorsed the bill in in State of the Union speech last week, saying he would "sign it tomorrow." Brown used that opening to briefly speak with the president as he was exiting the House chamber after Tuesday's address.

"The insider trading bill's on Harry's desk right now," Brown told Obama, referring to Senate Majority Leader Harry Reid. "Tell him to get it out, it's already there."

"I'm gonna tell him," answered Obama. "I'm gonna tell him, I'm gonna tell him to get it done."

Obama raised the issue again in his radio and Internet address on Saturday.

"The House and Senate should send me a bill that bans insider trading by members of Congress, and I will sign it immediately. They should limit any elected official from owning stocks in industries they impact," he said.

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20120129/ap_on_bi_ge/us_congress_insider_trading

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Researchers shed light on magnetic mystery of graphite

Friday, January 27, 2012

The physical property of magnetism has historically been associated with metals such as iron, nickel and cobalt; however, graphite ? an organic mineral made up of stacks of individual carbon sheets ? has baffled researchers in recent years by showing weak signs of magnetism.

The hunt for an explanation has not been without controversy, with several research groups proposing different theories. The most recent suggestion, published today, 27 January, in the journal EPL (Europhysics Letters), has been put forward by a research group from the University of Manchester that includes Nobel prize-winning scientist Professor Sir Andre Geim.

The research group, led by Dr Irina Grigorieva, found that magnetism in many commercially available graphite crystals is down to micron-sized clusters of predominantly iron that would usually be difficult to find unless the right instruments were used in a particular way.

Finding the way to make graphite magnetic could be the first step to utilising it as a bio-compatible magnet for use in medicine and biology as effective biosensors.

To arrive at their conclusions, the researchers firstly cut up a piece of commercially-available graphite into four sections and measured the magnetisation of each piece. Surprisingly, they found significant variations in the magnetism of each sample. It was reasonable for them to conclude that the magnetic response had to be caused by external factors, such as small impurities of another material.

To check this hypothesis, the researchers peered deep into the structure of the samples using a scanning electron microscope (SEM) ? a very powerful microscope that images samples by scanning it with a beam of electrons ? and found that there were unusually heavy particles positioned deep under the surface.

The majority of these particles were confirmed to be iron and titanium, using a technique known as X-ray microanalysis. As oxygen was also present, the particles were likely to be either magnetite or titanomagnetite, both of which are magnetic.

The researchers were also able to deduce how many magnetic particles would be needed, and how far apart they would need to be spaced in order to create the originally observed magnetism. The observations from their experiments agreed with their estimations, meaning the visualised magnetic particles could account for the whole magnetic signal in the sample.

Dr Grigorieva, said: "The excitement around the findings of ferromagnetism in graphite, i.e. pure carbon, is due to the fact that magnetism is not normally found in organic matter. If we can learn to create and control magnetism in carbon-based materials, especially graphene, this will be an important development for sensors and spintronics."

###

The paper can be downloaded from http://iopscience.iop.org/0295-5075/97/4/47001

Institute of Physics: http://www.iop.org

Thanks to Institute of Physics for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 97 time(s).

Source: http://www.labspaces.net/117149/Researchers_shed_light_on_magnetic_mystery_of_graphite

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Citigroup cut investment bank bonuses by 30 percent: report (Reuters)

(Reuters) ? Citigroup (C.N) has cut bonuses for its investment banking division by about 30 percent on average, Bloomberg said, citing a person briefed on the matter.

Some businesses within the securities and banking unit had bonuses reduced by as much as 70 percent, Bloomberg reported.

Citigroup was not immediately available for comment.

(Reporting by Abhiram Nandakumar in Bangalore; Editing by Steve Orlofsky)

Source: http://us.rd.yahoo.com/dailynews/rss/business/*http%3A//news.yahoo.com/s/nm/20120128/bs_nm/us_citigroup

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Saturday, January 28, 2012

Turkish state TV airs Holocaust film (AP)

ANKARA, Turkey ? Turkey has marked the international Holocaust Remembrance Day by airing a French epic documentary about the Holocaust.

TRT television's documentary channel showed filmmaker Claude Lanzmann's "Shoah" late on Thursday, on the eve of the remembrance day.

The filmaker said this is the first time the film was broadcast on state television in a Muslim country.

The documentary was aired as part of a campaign to promote understanding between Jews and Muslims and to fight Holocaust denial.

In March, a Los Angeles-based Farsi satellite channel had also broadcast the 9-plus-hour documentary in Iran, where President Mahmoud Ahmadinejad has questioned historical accounts of the Holocaust.

Lanzmann worked for 11 years on the film, which was released in 1985.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20120127/ap_on_re_eu/eu_turkey_holocaust_film

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Gingrich: Use Reagan approach for post-Castro Cuba (AP)

JACKSONVILLE, Fla. ? Republican presidential hopefuls are casting President Barack Obama as a failure on Cuba and say they would do a better job ushering freedom into the nation after Castro.

Newt Gingrich said during Thursday night's debate that the United States should use the same tactics President Ronald Reagan employed to bring down the Soviet Union. Gingrich says the U.S. policy should be to connect with young Cubans to persuade them that they want freedom for their generation.

Mitt Romney says he would use economic pressure to bring about freedom for the island nation 90 miles off Florida. Rick Santorum says Obama's policies to ease restrictions on Cuba are "the exact wrong message at the exact wrong time."

Ron Paul alone says the United States should engage Cuba now to ease tensions.

Source: http://us.rd.yahoo.com/dailynews/rss/obama/*http%3A//news.yahoo.com/s/ap/20120127/ap_on_el_pr/us_gop_debate_cuba

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Nintendo chief promises to do Wii U launch right (AP)

TOKYO ? Nintendo's chief is determined to get right the launch of its next game machine, Wii U, set for this year's holiday shopping season, and acknowledged Friday some mistakes with selling its 3DS handheld.

But Nintendo Co. President Satoru Iwata warned earnings for the fiscal year set to begin April will be the toughest ever for the Japanese manufacturer behind the Super Mario and Pokemon games.

Nintendo went against conventional wisdom with the original Wii in 2006. The quirky, cheap game console relied not on high-end graphics and complex buttons to lure in hardcore players, but on simple motion controls to lure in everyone.

Although the company successfully courted casual gamers with the Wii, it is now facing increased competition from Apple Inc.'s iPhone and other devices that offer simple games. It had hoped to win new gamers through a 3-D handheld device. But sales were slow, and Nintendo slashed prices on the 3DS within six months.

Iwata's remarks come a day after it lowered its annual earnings forecast to a 65 billion yen ($844 million) loss, much larger than the 20 billion yen ($260 million) loss projected earlier. It posted a 77.62 billion yen profit the previous fiscal year.

Iwata blamed the strong yen, which erases overseas earnings, as well as the arrival of smartphones and other devices that offer gaming.

The higher yen slashed nearly 54 billion yen ($701 million) from the company's operating profit for the April-December period.

"I can see how the red ink may be perceived as abnormal," Iwata told analysts and reporters at a Tokyo hotel. "The environment has changed."

The failure of the 3DS handheld to take off with enough momentum during the last quarter of 2011 was one of the main reasons for the dismal results, according to Iwata.

The 3DS has gradually started to sell better, but it took a price cut in August. It still lacks a strong lineup of attractive software games, a key factor for a machine to succeed in a big way.

Iwata vowed the company will be better prepared when it introduces the Wii U home console during the 2012 year-end shopping season for a strong comeback.

He declined to give details such as pricing or what the software games available at that time might be.

But he said the Wii U will come with a strong game lineup at the launch as well as secure and safe Internet services that will offer players individual accounts.

The Wii U will come with new ways of playing that will almost make the term "home console" obsolete, Iwata said. It will also offer mobile gaming. The machine has a touch-panel controller.

Nintendo has long competed against rival game makers, such as Sony Corp. and Microsoft Corp. These days, all face the threat from hit devices like the iPad and iPhone from Apple Inc. that also offer games.

Iwata's comments also showed Nintendo is growing less cautious about the Internet, which in the past it had brushed off as mainly for hard-core gamers.

Kyoto-based Nintendo has built its reputation on making games fun to play for casual and newcomer players.

"We are going to put to use our bitter experience with the 3DS," said Iwata.

___

Follow Yuri Kageyama at http://twitter.com/yurikageyama

Source: http://us.rd.yahoo.com/dailynews/rss/personaltech/*http%3A//news.yahoo.com/s/ap/20120127/ap_on_hi_te/as_japan_nintendo

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Survey suggests family history of psychiatric disorders shapes intellectual interests

Survey suggests family history of psychiatric disorders shapes intellectual interests

Friday, January 27, 2012

A hallmark of the individual is the cultivation of personal interests, but for some people, their intellectual pursuits might actually be genetically predetermined. Survey results published by Princeton University researchers in the journal PLoS ONE suggest that a family history of psychiatric conditions such as autism and depression could influence the subjects a person finds engaging.

Although preliminary, the findings provide a new look at the oft-studied link between psychiatric conditions and aptitude in the arts or sciences. While previous studies have explored this link by focusing on highly creative individuals or a person's occupation, the Princeton research indicates that the influence of familial neuropsychiatric traits on personal interests is apparently independent of a person's talent or career path, and could help form a person's basic preferences and personality.

Princeton researchers surveyed nearly 1,100 students from the University's Class of 2014 early in their freshman year to learn which major they would choose based on their intellectual interests. The students were then asked to indicate the incidence of mood disorders, substance abuse or autism spectrum disorder (ASD) in their family, including parents, siblings and grandparents.

Students interested in pursuing a major in the humanities or social sciences were twice as likely to report that a family member had a mood disorder or a problem with substance abuse. Students with an interest in science and technical majors, on the other hand, were three times more likely to report a sibling with an ASD, a range of developmental disorders that includes autism and Asperger syndrome.

Senior researcher Sam Wang, an associate professor in Princeton's Department of Molecular Biology and the Princeton Neuroscience Institute, said that the survey ? though not exhaustive nor based on direct clinical diagnoses ? presents the idea that certain heritable psychiatric conditions are more closely linked to a person's intellectual interests than is currently supposed.

During the past several decades, Wang said, various researchers have found that, in certain people and their relatives, mood or behavior disorders are associated with a higher-than-average representation in careers related to writing and the humanities, while conditions related to autism exhibit a similar correlation with scientific and technical careers.

By focusing on poets, writers and scientists, however, those studies only include people who have advanced far in "artistic" or "scientific" pursuits and professions, potentially excluding a large group of people who have those interests but no particular aptitude or related career, Wang said. He and lead author Benjamin Campbell, a graduate student at Rockefeller University, selected incoming freshmen because the students are old enough to have defined interests, but are not yet on a set career path. (Princeton students do not declare a major until the end of sophomore year.)

"Until our work, evidence of a connection between neuropsychiatric disorders and artistic aptitude, for example, was based on surveying creative people, where creativity is usually defined in terms of occupation or proficiency in an artistic field," Wang said. "But what if there is a broader category of people associated with bipolar or depression, namely people who think that the arts are interesting? The students we surveyed are not all F. Scott Fitzgerald, but many more of them might like to read F. Scott Fitzgerald."

The Princeton research provides a new and "provocative" consideration that other scientists in this area can build upon, said Kay Redfield Jamison, a psychiatry and behavioral science professor at Johns Hopkins University and co-director of the university's Mood Disorders Center.

Jamison, who is well known for her research on bipolar disorder and her work on the artistic/mood disorder connection, said that while interests and choice of career are presumably related, Wang and Campbell present data suggesting that intellectual interests might also be independently shaped by psychiatric conditions, which provides the issue larger context.

In addition, the researchers focused on an age group that is not typically looked at specifically, but that is usually included in analyses that span various ages. Such a targeted approach lends the results a unique perspective, she said. Though the incidence of psychiatric conditions in the Princeton study was based on the students' own reporting and not definitive diagnoses, the rates Wang and Campbell found are not different from other populations, she noted.

"This is an additional way of looking at a complex problem that is very interesting," said Jamison, who played no role in the research project. "This work provides a piece of the puzzle in understanding why people go into particular occupations. In this field, it's important to do as many different kinds of studies as possible, and this is an interesting initial study with very interesting findings. It will provoke people to think about this question and it will provoke people to design other kinds of studies."

An implied connection between psychiatric conditions and a flair for art or science dates to at least Aristotle, who famously noted that those "eminent in philosophy, politics, poetry and the arts have all had tendencies toward melancholia."

Modern explorations of that relationship have examined the actual prevalence of people with neuropsychiatric disorders and their relatives in particular fields.

Among the most recent work, researchers at Sweden's Karolinska Institute reported in the British Journal of Psychiatry in November that of the 300,000 people studied, people with bipolar disorder, as well as their healthy parents and siblings, were more likely to have a "creative" job ? including a field in the arts or sciences ? than people with no familial history of the condition. Parents and siblings of people with schizophrenia also exhibited a greater tendency to have a creative job, though people with schizophrenia did not.

Various other studies in the past few decades have found a similar correlation between psychiatric disorders and "creativity," which is typically defined by a person's career or eminence in an artistic field such as writing or music. In their work, however, Wang and Campbell present those criteria as too narrow. They instead suggest that psychiatric disorders can predispose a person to a predilection for the subject matter independent of any concrete measure of creativity.

Jamison, in an editorial regarding the Karolinska study and published in the same journal issue, wrote that "having a creative occupation is not the same thing as being creative." Wang and Campbell approached their project from the inverse of that statement: Being creative does not necessarily mean a person has a creative occupation.

"A person is not just what they do for a living," Wang said. "I am a scientist, but not just a scientist. I'm also a guy who reads blogs, listens to jazz and likes to cook. In that same respect, I believe we have potentially broadened the original assertion of Aristotle by including not just the artistically creative, but a larger category ? all people whose thought processes gravitate to the humanistic and artistic."

As past studies have, Wang and Campbell suggest a genetic basis for their results. The correlation with interests and psychiatric conditions they observed implies that a common genetic path could lead relatives in similar directions, but with some people developing psychiatric disorders while their kin only possess certain traits of those conditions. Those traits can manifest as preferences for and talents in certain areas, Wang said.

"Altogether, results of our study and those like it suggest that scientists should start thinking about the genetic roots of normal function as much as we discuss the genetic causes of abnormal function. This survey helps show that there might be common cause between the two," Wang said.

"Everyone has specific individual interests that result from experiences in life, but these interests arise from a genetic starting point," Wang said. "This doesn't mean that our genes determine our fate. It just means that our genes launch us down a path in life, leading most people to pursue specific interests and, in extreme cases, leading others toward psychiatric disorders."

###

Princeton University: http://www.princeton.edu

Thanks to Princeton University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/117145/Survey_suggests_family_history_of_psychiatric_disorders_shapes_intellectual_interests

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Making memories last: Prion-like protein plays key role in storing long-term memories

ScienceDaily (Jan. 27, 2012) ? Memories in our brains are maintained by connections between neurons called "synapses." But how do these synapses stay strong and keep memories alive for decades? Neuroscientists at the Stowers Institute for Medical Research have discovered a major clue from a study in fruit flies: Hardy, self-copying clusters or oligomers of a synapse protein are an essential ingredient for the formation of long-term memory.

The finding supports a surprising new theory about memory, and may have a profound impact on explaining other oligomer-linked functions and diseases in the brain, including Alzheimer's disease and prion diseases.

"Self-sustaining populations of oligomers located at synapses may be the key to the long-term synaptic changes that underlie memory; in fact, our finding hints that oligomers play a wider role in the brain than has been thought," says Kausik Si, Ph.D., an associate investigator at the Stowers Institute, and senior author of the new study, which is published in the January 27, 2012 online issue of the journal Cell.

Si's investigations in this area began nearly a decade ago during his doctoral research in the Columbia University laboratory of Nobel-winning neuroscientist Eric Kandel. He found that in the sea slug Aplysia californica, which has long been favored by neuroscientists for memory experiments because of its large, easily-studied neurons, a synapse-maintenance protein known as CPEB (Cytoplasmic Polyadenylation Element Binding protein) has an unexpected property.

A portion of the structure is self-complementary and -- much like empty egg cartons -- can easily stack up with other copies of itself. CPEB thus exists in neurons partly in the form of oligomers, which increase in number when neuronal synapses strengthen. These oligomers have a hardy resistance to ordinary solvents, and within neurons may be much more stable than single-copy "monomers" of CPEB. They also seem to actively sustain their population by serving as templates for the formation of new oligomers from free monomers in the vicinity.

CPEB-like proteins exist in all animals, and in brain cells they play a key role in maintaining the production of other synapse-strengthening proteins. Studies by Si and others in the past few years have hinted that CPEB's tendency to oligomerize is not merely incidental, but is indeed essential to its ability to stabilize longer-term memory. "What we've lacked till now are experiments showing this conclusively," Si says.

In the new study, Si and his colleagues examined a Drosophila fruit fly CPEB protein known as Orb2. Like its counterpart in Aplysia, it forms oligomers within neurons. "We found that these Orb2 oligomers become more numerous in neurons whose synapses are stimulated, and that this increase in oligomers happens near synapses," says lead author Amitabha Majumdar, Ph.D., a postdoctoral researcher in Si's lab.

The key was to show that the disruption of Orb2 oligomerization on its own impairs Orb2's function in stabilizing memory. Majumdar was able to do this by generating an Orb2 mutant that lacks the normal ability to oligomerize yet maintains a near-normal concentration in neurons. Fruit flies carrying this mutant form of Orb2 lost their ability to form long-term memories. "For the first 24 hours after a memory-forming stimulus, the memory was there, but by 48 hours it was gone, whereas in flies with normal Orb2 the memory persisted," Majumdar says.

Si and his team are now following up with experiments to determine for how long Orb2 oligomers are needed to keep a memory alive. "We suspect that they need to be continuously present, because they are self-sustaining in a way that Orb2 monomers are not," says Si.

The team's research also suggests some intriguing possibilities for other areas of neuroscience. This study revealed that Orb2 proteins in the Drosophila nervous system come in a rare, highly oligomerization-prone form (Orb2A) and a much more common, much less oligomerization-prone form (Orb2B). "The rare form seems to be the one that is regulated, and it seems to act like a seed for the initial oligomerization, which pulls in copies of the more abundant form," Si says. "This may turn out to be a basic pattern for functional oligomers."

The findings may help scientists understand disease-causing oligomers too. Alzheimer's, Parkinson's and Huntington's disease, as well as prion diseases such as Creutzfeldt-Jakob disease, all involve the spread in the brain of apparently toxic oligomers of various proteins. One such protein, strongly implicated in Alzheimer's disease, is amyloid beta; like Orb2 it comes in two forms, the highly oligomerizing amyloid-beta-42 and the relatively inert amyloid-beta-40. Si's work hints at the possibility that oligomer-linked diseases are relatively common in the brain because the brain evolved to be relatively hospitable to CPEB proteins and other functional oligomers, and thus has fewer mechanisms for keeping rogue oligomers under control.

Other researchers who contributed to the work include Wanda Col?n Cesario, Erica White-Grindely, Huoqin Jian, Fangzhen Ren, Mohammed 'Repon' Khan, Liying Li, Edward Man-Lik Choi, Kasthuri Kannan, Feng Li, Jay Unruh and Brian Slaughter at the Stowers Institute for Medical Research in Kansas City, Missouri.

The research was supported by the Searle Foundation, the March of Dimes Basil O'Connor Starter Award, the Klingenstein Foundation and the McKnight Foundation.

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Journal Reference:

  1. Amitabha Majumdar, Wanda Col?n Cesario, Erica White-Grindley, Huoqing Jiang, Fengzhen Ren, Mohammed ?Repon? Khan, Liying Li, Edward Man-Lik Choi, Kasthuri Kannan, Fengli Guo et al. Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory. Cell, 26 January 2012 DOI: 10.1016/j.cell.2012.01.004

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/VZp3lMiJGDo/120127162409.htm

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GOP hopefuls say they will release health records

CORRECTS LOCATION TO THE UNIVERSITY OF NORTH FLORIDA, INSTEAD OF UNIVERSITY OF SOUTH FLORIDA - Republican presidential candidates, from left, former Pennsylvania Sen. Rick Santorum, former House Speaker Newt Gingrich, former Massachusetts Gov. Mitt Romney and Rep. Ron Paul, R-Texas, stand during the National Anthem at the Republican presidential candidates debate at the University of North Florida in Jacksonville, Fla., Thursday, Jan. 26, 2012. (AP Photo/Paul Sancya)

CORRECTS LOCATION TO THE UNIVERSITY OF NORTH FLORIDA, INSTEAD OF UNIVERSITY OF SOUTH FLORIDA - Republican presidential candidates, from left, former Pennsylvania Sen. Rick Santorum, former House Speaker Newt Gingrich, former Massachusetts Gov. Mitt Romney and Rep. Ron Paul, R-Texas, stand during the National Anthem at the Republican presidential candidates debate at the University of North Florida in Jacksonville, Fla., Thursday, Jan. 26, 2012. (AP Photo/Paul Sancya)

(AP) ? The Republicans running for their party's presidential nomination say they will release their medical records if they are picked.

Ron Paul is the 76-year-old congressman from Texas. He was asked Monday if he would release his health records given he would be the nation's oldest president if he wins. Paul says he will and then challenged his younger rivals to a 25-mile bike ride.

Newt Gingrich, Mitt Romney and Rick Santorum all say they also will release their records. Gingrich joked that he has watched Paul campaign and says Paul is "in great shape."

Paul chided moderator Wolf Blitzer for the question. He says there are laws against age discrimination.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2012-01-26-GOP%20Debate-Medical%20Records/id-1f2da7061a8348f4b45a42c98c40f6cd

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Friday, January 27, 2012

Video: Dimon on World Economy, Geithner & Bernanke

James Dimon, chairman, president & CEO, JPMorgan Chase, discusses the world economy, muddling through in Europe, and the President's prerogative when it comes to naming a successor for Treasury Secretary Timothy Geithner. Bernanke, he says, has been an...

Source: http://video.msnbc.msn.com/cnbc/46145481/

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#Humblebrag: Jack Dorsey, Reid Hoffman, Kevin Rose Coming To The Crunchies; Harris Wittels Hosting

normalAfter writing for NBC's Parks and Recreation for the past couple years (he's about to start a writing gig for HBO's Eastbound and Down), and authoring the sarcastic but brilliant and hilarious @HumbleBrag, Harris Wittels has decided to bring his talents to TechCrunch. This year, he will be hosting the Crunchies Awards, and bringing his chiding humor. If you're not familiar with Humblebrag, he scours Twitter in search of ?braggadocio wrapped in humility. I'm willing to bet at least one of you has been retweeted. If so, post them in the comments below. We want to see. Not only is Wittels hosting, but Jack Dorsey, Kevin Rose, Marissa Mayer, Kevin Systrom, Reid Hoffman, Ron Conway and many more will also be joining us, many of them presenting awards themselves.?This is going to be one night you won't want to miss. We have just released our last batch of tickets. If you would like to come to the Crunchies Awards, make sure to go here to get them, and get them quickly since they tend to sell very fast. And there's still time to vote for the best startups, apps, investors, and founders of the year. Voting ends at midnight on Sunday.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/4ciFNaEtBo0/

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Britain's first breast cancer tissue bank opens

Britain's first breast cancer tissue bank has opened for business, supplying tumour samples to scientists around the UK.

Funded by the charity Breast Cancer Campaign, the bank has around 2,500 samples housed at four centres in London, Leeds, Nottingham, and Dundee.

The samples will help researchers gather vital information about different types of breast cancer which could lead to better diagnosis and treatment.

Previously, scientists could spend many months tracking down the right tissue samples for their research.

Science minister David Willetts said: "The Breast Cancer Campaign Tissue Bank is a fantastic example of how an innovative idea from researchers can become a reality. Collaborative working between the voluntary sector, universities and the NHS has culminated in a unique project that will not only make a real difference to scientists, but also has the potential to improve health and save lives."

Baroness Morgan, chief executive of the Breast Cancer Campaign, said: "Breast cancer researchers in the UK and Ireland have been crying out for this resource for many years. The Tissue Bank will provide a source of precious human breast tissue and puts an end to the serious access problems of the past."

Source: http://rss.feedsportal.com/c/845/f/464365/s/1c2b9c52/l/0L0Sbelfasttelegraph0O0Cnews0Chealth0Cbritains0Efirst0Ebreast0Ecancer0Etissue0Ebank0Eopens0E1610A96350Bhtml0Dr0FRSS/story01.htm

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